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Research Interests
Our laboratory is involved in basic and applied genetic research in fishes, especially trout and salmon. We utilize a variety of chromosome set manipulation procedures to trout and salmon to increase our understanding of basic genetics in these fishes and for their genetic improvement. Androgenesis and gynogenesis involve producing offspring with both chromosome sets from one parent and can be useful for producing inbred lines, gene mapping and other studies. Triploids can also be readily produced and are of interest because they are sterile and because triploid interspecific hybrids have been demonstrated frequently to be much more viable than diploid hybrids. Our laboratory is also analyzing DNA polymorphisms in trout and salmon with the goals of developing improved genetic maps, identifying markers for conservation programs and identifying single genes with significant physiological effects.
Representative Publications
Brown, K.H., R.W. Lee, and G.H. Thorgaard, 2006. Use of androgenesis for estimating maternal and mitochondrial haplotype effects on development and oxygen consumption in rainbow trout, Oncorhynchus mykiss. Comp. Biochem. Physiol. B: 143: 415-421.
Sundin, K., K.H. Brown, R.E. Drew, K.M. Nichols, P.A. Wheeler and G.H. Thorgaard, 2005 Genetic analysis of a development rate QTL in backcrosses of clonal rainbow trout. Aquaculture 247: 75-83.
Felip, A., A. Fujiwara, W.P. Young, P.A. Wheeler, M. Noakes, R.B. Phillips and G.H. Thorgaard, 2004. Polymorphism and differentiation of rainbow trout Y chromosomes. Genome 47: 1105-1113.
Lucas, M.D. R.E. Drew, P.A Wheeler, P.A. Verrell and G.H Thorgaard, 2004. Behavioral differences among rainbow trout clonal lines. Behavior Genetics 34: 355-365.
Zimmerman, A.M, J.P. Evenhuis, G.H. Thorgaard and S.S. Ristow, 2004. A single major chromosomal region controls natural killer cell-like activity in rainbow trout. Immunogenetics 55: 825-835.
Thorgaard, G.H., G.S. Bailey, D. Williams, D.R. Buhler, S.L. Kaattari, S.S. Ristow, J.D. Hansen, J.R. Winton, J.L. Bartholomew, J.J. Nagler, P.J. Walsh, M.M. Vijayan, R.H. Devlin, R.W. Hardy, K.E. Overturf, W.P. Young, B.D. Robison, C. Rexroad III, Y. Palti, 2002. Status and opportunities for genomics research with rainbow trout. Comp. Biochem. Physiol. B., 133: 609-646.