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Research Interests
My primary focus is on ion transport across insect epithelia. I am interested in how epithelia move ions across and within themselves and how these processes are adapted to meet environmental challenges. Our current interest is in the cellular mechanisms that enable some insects to maintain extremely alkaline gut environments.
Representative Publications
Onken, H., Moffett, S.B. and Moffett, D.F. (2006) The isolated anterior stomach of larval mosquitoes (Aedes aegypti): voltage-clamp measurements with a tubular epithelium. Comp. Biochem. Physiol. A, 143, 24-34.
Clark, T.M., Hutchinson, M.J., Huegel, K.L., Moffett, S.B. and Moffett, D.F. (2005) Additional morphological and physiological heterogeity within the midgut of larval Aedes aegypti (Diptera: Culicidae) revealed by histology, electrophysiology, and effects of Bacillus thuringiensis endotoxin. Tissue & Cell 37, 457-468.
Onken, H., Moffett, S.B. and Moffett, D.F. (2004) The anterior stomach of larval mosquitoes (Aedes aegypti): effects of neuropeptides on transepithelial ion transport and muscular motility. J. Exp. Biol. 207, 3731-3739.
Clark, T. M., A. R. Koch, and D. F. Moffett, 1998. Alkalinization by Manduca serta anterior midgut in vittro: Requirements and characteristics. Comp. Biochem. Physiol., 121A: 181-187.
Klein, U., A. R. Koch, and D. F. Moffett, 1996. Ion Transport in lepidopteran midgut, Chap. 9 in The Insect Midgut, Lehane and Billingsly, eds. Chapman & Hall.
Silverstein, L. J., B. G. Swanson,and D. F. Moffett, 1996. Procyanidin from black beans (Phaseolus vulgaris) inhibits nutrient and electrolyte absorption in isolated rat ileum and induces a secretory state. J. Nutrition 126: 1688-1695.