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Research Interests
Research in my laboratory is aimed at understanding ion transport across epithelia, predominantly those, like skins and gills, at the body surface. Much of the attention is devoted to the molecular mechanisms involved in moving ions across epithelial cell membranes. Other aspects are more holistic and look at the role(s) of such epithelia in regulating the ionic composition of the extracellular body fluids; i.e., in ionic and osmotic regulation in different environments. Our approach is comparative; the systems in lower vertebrates and invertebrates are as interesting and challenging as those in mammals, but receive much less attention.
Representative Publications
Kirschner, L. B. 1997. Extrarenal mechanisms in hydromineral and acid-base regulation in aquatic vertebrates. In Handbook of Physiology, Sect. 13, Vol. 1 (Dantzler, W. H., ed.). Oxford University Press, New York. p. 577-622.
Kirschner, L. B. 1997. Ambient ions and the voltage across crayfish gills. In Ionic Regulation in Animals (Hazon, N., Eddy, F. B., and Flik, G., eds.). Springer, Berlin. p. 26-32.
Kirschner, L. B. 1995. The energetics of osmoregulation in fresh water vertebrates. J. of Exp. Zool. 271: 243-252.